Endocrine Abstracts

As for many tumor types, it has been shown that the Akt pathway is overexpressed and activated in human pituitary tumors. Thus, pituitary tumors may be sensitive to the anti-proliferative effects of mTOR inhibitors. However, part of non-functioning pituitary tumors are rapamycin-resistant. Torin1, second-generation ATP-competitive mTOR kinase inhibitor, suppresses both mTORC1 and mTORC2 complexes. To evaluate the in vitro effects of the mTOR inhibitor Torin1 on pituitar...

IGF-I receptors (IGF-IR) and their aberrant signaling cascade contribute to the pathogenesis of several solid cancers. Pituitary adenomas express IGF-IR and present with overactivation of the IGF-IR pathway. The aim of the study was to identify the potential antiproliferative action of the small molecule IGF-IR inhibitor NVP-TAE226 on acromegalic (n=11) and nonfunctioning pituitary adenomas (NFPA; n=15) in primary cell culture. Changes in cell viability were dete...